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Table 2 Acute stress exposure elevated the number of microglia in numerous brain regions

From: Social defeat induces depressive-like states and microglial activation without involvement of peripheral macrophages

Area

HC

Acute SD

Chronic SD

ANOVA F (2,23)

IL

68.75 ± 3.38

87.33 ± 4.2a

59.14 ± 1.91

16.71, p < 0.001

PL

105.5 ± 3.47

123.66 ± 3.24a

99 ± 4.94

9.28, p < 0.001

CG

148.72 ± 6.36

193.83 ± 6.83a

126.5 ± 4.54

29.11, p < 0.001

PIR

75.43 ± 6.19

94.5 ± 2.67a

74.75 ± 4.26

5.26, p < 0.02

Acb

153.97 ± 2.62

173.96 ± 6.47b

128.43 ± 12.44

6.83, p < 0.01

dBST

49.29 ± 1.94

45.66 ± 3.71

47.75 ± 2.98

 

vBST

60.57 ± 6.29

63.33 ± 2.15

67.87 ± 4.47

 

PVN

104.5 ± 8.92

109.28 ± 6.55

117.37 ± 11.34

 

Dorsal DG

214.3 ± 10.17

275.4 ± 6.6a

219.42 ± 11.54

11.1, p < 0.001

BLA

96.43 ± 5.17

148.75 ± 5.28a

115 ± 4.85

24.12, p < 0.001

DR

88.75 ± 7.82

95.2 ± 3.17

87.4 ± 5.03

 

PAG

194.33 ± 9.2

181.6 ± 3.14

167 ± 11.4

 
  1. The number of microglia in examined brain regions of CX3CR1GFP/+ mice housed either in homecage (HC) or exposed to social defeat for 3 days (acute SD) or 14 days (chronic SD). Values are expressed as mean ± SEM (n = 8 per group). Means with (a) indicate significant difference versus all other groups (p < 0.01). Means with (b) indicate significance versus chronic SD samples (p < 0.01). F values obtained from one-way ANOVAs for microglia number in each brain region