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Table 3 Exposure to acute psychological stress substantially elevates microglia proliferation in numerous brain regions

From: Social defeat induces depressive-like states and microglial activation without involvement of peripheral macrophages

Area

HC

Acute SD

Chronic SD

ANOVA F (2,23)

IL

0.2 ± .17

23.6 ± 2.27a

0

101.7, p < 0.001

PL

0.2 ± .17

26.7 ± 2.48a

0

109.5, p < 0.001

CG

0.4 ± .3

35.1 ± 2.04a

0

272.5, p < 0.001

PIR

0

21.8 ± 2.44a

0.2 ± 0.1

76.88, p < 0.001

Acb

0.6 ± 0.36

23.1 ± 2.89a

0

57.89, p < 0.001

dBST

0

0.7 ± 0.4

0

 

vBST

0.25 ± .2

1.2 ± 0.4

0

 

PVN

1.0 ± 0.5

7.0 ± 3.0

0.2 ± 0.1

 

Dorsal DG

2.7 ± 0.8

19.66 ± 2.1a

0.6 ± 0.3

65.13, p < 0.001

BLA

0

5.0 ± 1.7a

0

8.34, p < 0.005

DR

0

7.0 ± 1.1a

0

46.67, p < 0.001

PAG

1.0 ± 0.4

13.5 ± 2.0a

0

40.27, p < 0.001

  1. The number of microglia colocalized with a S phase proliferation marker (PCNA proliferating cell nuclear antigen) in examined brain regions of CX3CR1GFP/+ mice housed either in homecage (HC) or exposed to social defeat for 2 days (acute SD) or 14 days (chronic SD). Confocal microscopy was used to determine colocalization, and values shown above are expressed as mean ± SEM (n = 8 per group). F values obtained from one-way ANOVAs for microglia number in each brain region. Means with (a) indicate significant difference versus all other conditions (p < 0.01)