Skip to main content

Table 3 Exposure to acute psychological stress substantially elevates microglia proliferation in numerous brain regions

From: Social defeat induces depressive-like states and microglial activation without involvement of peripheral macrophages

Area HC Acute SD Chronic SD ANOVA F (2,23)
IL 0.2 ± .17 23.6 ± 2.27a 0 101.7, p < 0.001
PL 0.2 ± .17 26.7 ± 2.48a 0 109.5, p < 0.001
CG 0.4 ± .3 35.1 ± 2.04a 0 272.5, p < 0.001
PIR 0 21.8 ± 2.44a 0.2 ± 0.1 76.88, p < 0.001
Acb 0.6 ± 0.36 23.1 ± 2.89a 0 57.89, p < 0.001
dBST 0 0.7 ± 0.4 0  
vBST 0.25 ± .2 1.2 ± 0.4 0  
PVN 1.0 ± 0.5 7.0 ± 3.0 0.2 ± 0.1  
Dorsal DG 2.7 ± 0.8 19.66 ± 2.1a 0.6 ± 0.3 65.13, p < 0.001
BLA 0 5.0 ± 1.7a 0 8.34, p < 0.005
DR 0 7.0 ± 1.1a 0 46.67, p < 0.001
PAG 1.0 ± 0.4 13.5 ± 2.0a 0 40.27, p < 0.001
  1. The number of microglia colocalized with a S phase proliferation marker (PCNA proliferating cell nuclear antigen) in examined brain regions of CX3CR1GFP/+ mice housed either in homecage (HC) or exposed to social defeat for 2 days (acute SD) or 14 days (chronic SD). Confocal microscopy was used to determine colocalization, and values shown above are expressed as mean ± SEM (n = 8 per group). F values obtained from one-way ANOVAs for microglia number in each brain region. Means with (a) indicate significant difference versus all other conditions (p < 0.01)