Fig. 4

Changes in gene expressions in spinal cord post intraplantar injection of saline or carrageenan. The ipsilateral dorsal horns of spinal cords were collected at 30 h post injection; mRNA levels are relative to β-actin. mRNA levels of receptors for resolvin D and resolvin E—FPR2/ALX (a) and ChemR23 (b), respectively, enzymes involved in resolvin biosynthesis-5-LOX (c) and 15-LOX (d), activating protein for 5-LOX—FLAP (e), pro-inflammatory enzyme—COX-2 (f) and anti-inflammatory cytokine—IL-10 (g). Data expressed as mean ± SEM. *p < 0.05 Mann-Whitney U test. Saline-treated n = 6, carrageenan-treated n = 5. FPR2/ALX formyl peptide receptor 2, ChemR23 chemerin receptor 23, FLAP 5-lipoxygenase-activating protein, LOX lipoxygenase, COX-2 cyclooxygenase-2, IL-10 interleukin-10