Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models

Table 2 Mean maximal percentage inhibition of evoked responses by AT-RvD1

Group effect (% maximal inhibition)
	Saline-treated	Carrageenan-treated
	AT-RvD1 (n = 10)	AT-RvD1 (n = 9)	AT-RvD1 post BOC-2 (n = 8)^a
Aβ	2 ± 9	11 ± 13	5 ± 9
Aδ	−14 ± 12	27 ± 7*	−13 ± 8^#
C	−10 ± 10	29 ± 5**	−1 ± 6^#
PD	−19 ± 23	46 ± 8	−9 ± 14^#
Input	−19 ± 15	41 ± 8*	−9 ± 14
WU	−10 ± 15	53 ± 12**	−1 ± 7^#

Comparison of group effects of AT-RvD1 (15 ng/50 μl) on electrically evoked responses of spinal WDR neurones in carrageenan-treated rats versus saline-treated rats and the effects of pre-treatment with BOC-2 50 μg/50 μl (expressed as % maximal inhibition). AT-RvD1 significantly inhibited a number of evoked parameters in carrageenan-treated-rats but not saline-treated rats. Pre-treatment with BOC-2 significantly prevented the inhibitory effects of AT-RvD1 for most of the parameters. Note that negative values indicate facilitation
*p < 0.05, **p < 0.01 compared to AT-RvD1 in the saline-treated group, ^# p < 0.05 compared to AT-RvD1 in the carrageenan-treated group without BOC-2, Kruskal-Wallis test with Dunn’s post hoc test
^aOne neurone was inhibited by BOC-2 and was excluded from further analysis

ISSN: 1742-2094