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Table 4 Effects of spinal AT-RvD1 versus morphine on evoked responses of spinal neurones in MIA- and saline-treated rats

From: Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models

 

Saline-treated (n = 7)

MIA-treated (n = 9)

 

AT-RvD1

Morphine 1 μg

AT-RvD1

Morphine 1 μg

15 ng

150 ng

15 ng

150 ng

Aβ

5 ± 7

6 ± 5

28 ± 6

1 ± 8

1 ± 9

2 ± 7#

Aδ

−5 ± 10

−10 ± 13

47 ± 7

11 ± 8

14 ± 10

40 ± 6

C

−4 ± 7

−13 ± 9

60 ± 14

10 ± 7

3 ± 8

35 ± 8

PD

−6 ± 14

−16 ± 15

70 ± 12

16 ± 24

9 ± 14

55 ± 9

Input

−5 ± 15

−19 ± 21

71 ± 12

−2 ± 12

2 ± 14

58 ± 11

WU

−12 ± 13

−20 ± 16

62 ± 13

17 ± 19

12 ± 12

34 ± 6

  1. Comparison of group effects of AT-RvD1 (15, 150 ng/50 μl) and morphine (1 μg/50 μl) on electrically evoked responses of spinal WDR neurones in MIA-treated rats versus saline-treated rats, expressed as % maximal inhibition. Note that negative values indicate facilitation
  2. # p < 0.05 Mann-Whitney U test versus saline-treated rats