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Table 2 Standardized estimates and p values of the group effects and the contrasts for plasma. This table provides the standardized estimates and p values for the group effects (POCD/delirium (DLR) or no POCD/DLR) and the contrasts for plasma in the linear mixed effects model. The time*group interaction is not significant for any of the markers. Assessment of change at each postoperative time point was only for the plasma cytokines that have a (marginally) significant overall time trend. The contrasts “change from the preoperative measure to 3 h,” “change from the preoperative measure to 6 h,” and “change from the preoperative measure to 18 h” signify whether there was a significant change in the concentration of a specific marker at 3, 6, and 18 h after surgery compared to the preoperative measurement

From: Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery

Marker (plasma)

Change from the pre-op to 3 h

Change from the pre-op to 6 h

Change from the pre-op to 18 h

POCD/delirium*

Plasma amyloid β-42

−0.4978

−1.9768*

0.1621

–

Plasma IL-5

 Group 1

0.3460

1.8097

2.4810**

2.0170*

 Group 0

−2.1696*

−1.2485

1.3206

Plasma IL-6

0.6607

5.0300***

7.5368***

–

Plasma IL-8

 Group 1

2.7407**

7.0220***

7.6799***

2.0873*

 Group 0

−0.0862

3.5706***

4.1325***

Plasma IL-10

1.3315

2.9038***

5.1079***

–

Plasma MCP-1

1.8755*

4.3376***

1.8720*

–

Plasma IL-6/IL-10

0.7498

1.6455

3.5501***

 

Plasma MIP-1α

2.9280**

2.7353**

1.2621

–

  1. The standardized estimates were calculated by dividing the estimated values by the corresponding standard errors to achieve the same scale. The asterisks indicate the level of significance for the hypothesis that the group effect/contrast is different from zero. For plasma IL-5 and plasma IL-8, the comparisons between postoperative measures to the preoperative measure are displayed separately for the two groups (group 1 = POCD/DLR, group 0 = no POCD/DLR), since the groups’ main effect is marginally significant for these two markers. Of note, the time*group interaction is still not significant. All values are in pg ml−1. See Fig. 2 for explanation of the group effect on the differences between the preoperative (pre-op) measure and each postoperative measure
  2. *0.05 < p value < 0.1; **0.01 < p value < 0.05; ***p value < 0.01
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Journal of Neuroinflammation

ISSN: 1742-2094