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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Type-1 angiotensin receptor signaling in central nervous system myeloid cells is pathogenic during fatal alphavirus encephalitis in mice

Fig. 4

Telmisartan has no effect on the replication or clearance of NSV from the brains (a) or spinal cords (b) of NSV-infected animals. Mice were inoculated with NSV and treated with telmisartan (100 mg/kg/day) or a vehicle control. Replicate mice were sacrificed at predetermined intervals, and viral titers were measured in each tissue sample by plaque titration assay. Mean ± SEM of the log10 of tissue plaque-forming units (pfu) per gram of tissue are shown. Two-way ANOVA confirmed that the virus replication curves from vehicle- and telmisartan-treated mice are not different from each other (p = 0.74 for brain, p = 0.31 for spinal cord)

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Journal of Neuroinflammation

ISSN: 1742-2094