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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Type-1 angiotensin receptor signaling in central nervous system myeloid cells is pathogenic during fatal alphavirus encephalitis in mice

Fig. 5

Telmisartan has no effect on the local CNS inflammatory response induced following NSV infection. At peak inflammation (day 6), total MNC infiltration was not suppressed in either the brains or spinal cords of mice (n = 5 mice per group) treated with telmisartan (100 mg/kg/day) compared to a vehicle control (a). By flow cytometry, the proportions of different brain-infiltrating myeloid cell subsets (CD45+/CD11b+) were not different between these two groups (b). Likewise, expression of CD40 (c) and CD86 (d) were not changed on any resident or CNS-infiltrating myeloid cell subset in the setting of drug treatment as assessed by the mean fluorescence intensity (MFI) of staining for the two activation markers

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Journal of Neuroinflammation

ISSN: 1742-2094