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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Type-1 angiotensin receptor signaling in central nervous system myeloid cells is pathogenic during fatal alphavirus encephalitis in mice

Fig. 9

In vivo labeling shows that ROS are induced in ventral gray matter of the lumbar spinal cord (outlined) following NSV challenge and that ROS induction is suppressed in infected animals treated with telmisartan. ROS-containing cells (red) were labeled by injecting mice with DHE just prior to sacrifice as described in the “Methods” section. A GFP-expressing virus was used to identify NSV-infected neurons (green). Negligible ROS staining was observed in uninfected control animals (a). Four days after NSV challenge, ROS were detected in relative proximity to, but not necessarily within, infected neurons (b). Telmisartan administration (100 mg/kg/day) abolished nearly all ROS labeling in infected animals at this time point (c). Calibration bar = 75 μm for all panels

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