Fig. 6

CD11b-positive cells in MASP-2^−/− but not in MASP-1/3^−/−mice appear with attenuated hypertrophic and amoeboid morphology indicative of a less activated state. Representative images of CD11b-positive cells showing morphologically different cells in WT, MASP-2^−/−, and MASP-1/3^−/− mice (a). CD11b cells in MASP-2^−/− mice present smaller area (b), lower Feret’s diameter (c), and lower solidity index (d) compared to WT. No differences were detected in MASP-1/3^−/− mice when compared to their WT controls. Data are reported as scatter-dot plots with means. Each dot represents the mean of all the cells acquired in one mouse. *P < 0.05; **P < 0.01, unpaired t test. Scale bar = 20 μm