Fig. 7

Effect of EFX treatment on CCI-induced neuronal degeneration in rats 2 days post-injury. EFX (50 mg/kg, i.p.) or its vehicle were administered 30 min after surgery and 24 h after (n = 5/group). Neuronal degeneration was evaluated with fluoro-jade B (FJB) staining. TBI induced an increase in FJB staining in the ipsilateral side of the injury (p < 0.001). EFX treatment significantly reduced neuronal degeneration (p < 0.001) in injured animals in comparison with vehicle treatment. Images show representative sections from each group (ipsilateral and contralateral side). Data are mean + SEM. ^### p < 0.001: comparison between sham-vehicle and TBI-vehicle groups; ***p < 0.001: comparison between TBI-vehicle and TBI-EFX groups