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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Cellular investigations with human antibodies associated with the anti-IgLON5 syndrome

Fig. 1

Epitope analysis of IgLON5 antibodies. The diagrams depict the complete IgLON5 (bottom) and mutated clones (left). Immunofluorescence of transfected HEK293 cells with the full length or the mutant IgLON5 clones (right). Rows correspond to the indicated clone in the diagram. The serum with IgLON5 antibodies (green) only targets the clones containing the immunoglobulin-like domain 2 (Ig2, left column). IgLON5 commercial antibody immunoreactivity is shown in the central column (in red) and both reactivities are shown merged in the right column. Nuclei counterstained with DAPI (blue). Scale bar = 10 μm. The (*) indicates the epitope recognized by the IgLON5 commercial antibody

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