Fig. 9From: Cellular investigations with human antibodies associated with the anti-IgLON5 syndromeIgG1 IgLON5 antibodies internalize IgLON5 clusters. Hippocampal neurons treated for 3 days with total IgG, IgG1, and IgG4 IgLON5 antibodies. The immunofluorescence strategy to differentiate surface and internal human IgG bound to IgLON5 is conducted as in Fig. 8. The IgG1 antibodies alone could reproduce the same effects seen with the total IgG; meanwhile, the IgG4 did not produce internalization. Scale bar = 5 μmBack to article page