Fig. 3
From: The crucial role of Erk2 in demyelinating inflammation in the central nervous system
Erk2 cKO mice are less sensitive to cuprizone-induced demyelination. Erk2 cKO or Erk2 flox/flox mice were fed with cuprizone for 1 to 10 weeks before histological examination. a Representative LFB staining shows ameliorated demyelination in Erk2 cKO mice compared with Erk2 flox/flox mice. Scale bar, 50 μm. b The severity of demyelination compared between Erk2 cKO and Erk2 flox/flox mice using a demyelination score. Statistical differences are observed at 4, 5, and 6 weeks of cuprizone feeding (n = 3 to 5; Mann-Whitney U test at each time point; *p < 0.05; **p < 0.01). Individual symbols represent individual animals