Fig. 6

Erk2 cKO and Erk2 ^flox/flox mice manifest similar reactions in the early phase of the cuprizone model. Damage to oligodendrocytes is quantified as decreases in the level of expression of the myelin-related molecules MBP (a) and MAG (b). No significant differences are seen between Erk2 cKO and Erk2 ^flox/flox after cuprizone feeding. n = 4; Student’s t test. c Activation of microglia analyzed by immunoblotting of Iba-1, which reveals differences between Erk2 cKO and Erk2 ^flox/flox at 4 weeks but not at 1 week of cuprizone feeding. d quantitative analysis: n = 4; Student’s t test; **p < 0.01