Fig. 5
From: β-Catenin signaling positively regulates glutamate uptake and metabolism in astrocytes
β-Catenin positively regulates GLT-1 and GS in vivo. Male 10C57bl/6J mice were microinjected with control, antisense (AS), or AS2 vivo-morpholinos against β-catenin on days 1 and 3 into the mPFC (a). On day 7, mice were sacrificed and brain harvested and β-catenin (b), GLT-1 (c), and GS (d) protein levels were measured by WB in AS treated with a KD of β-catenin. The panel (e) is a representative WB of animals treated with control, AS2, AS with KD of β-catenin, and AS without KD of β-catenin. Asterisks indicate a p < 0.05 relative to the respective control using Student’s t test. Error bars indicate SD