Fig. 1
From: α-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses
Reduced α-synuclein expression during EAE. a Clinical course of MOG35–55-induced EAE in C57BL/6N mice. Arrows indicate days prior to or post symptom onset on which α-synuclein mRNA expression was analyzed in the spleen (b) and spinal cord (c). b, c RT-PCR revealed a gradual downregulation of α-synuclein mRNA expression in the spleen and spinal cord (n = 4; *p < 0.05, **p < 0.01). d Western blot of spinal cord lysates from EAE mice 10 days after immunization (i.e., prior to symptom onset) demonstrates a significant reduction of α-synuclein (α-syn) protein as compared to the native spinal cord (n = 4; **p < 0.01)