Table 1 Demographic features of patients with MS according to region

Number of males/females (ratio)

120/314 (1:2.6)

62/185 (1:3.0)

58/129 (1:2.2)

NS

Age (years)^a

41 (33–50)

41 (34–50)

40 (32–50)

NS

Age at onset (years)^a

29 (22–38)

29 (22–36)

30 (23–40)

NS

SPMS (%)

73/427 (17.1)

53/245 (21.6)

20/182 (11.0)

0.0039

Disease duration (years)^a

9 (4–15)

10 (6–17)

6.5 (3–13)

<0.0001

EDSS^a

2.0 (1.0–3.5)

2.0 (1.0–3.5)

2.0 (1.0–3.5)

NS

MSSS^a

2.60 (0.94–5.50)

2.13 (0.69–5.24)

3.54 (1.45–5.90)

0.003

ARR^a

0.41 (0.22–0.75)

0.41 (0.24–0.73)

0.40 (0.20–0.89)

NS

Barkhof criteria (%)

318/428 (74.3)

198/247 (80.2)

120/181 (66.3)

0.0012

Positive OB and/or increased IgG index (%)

193/329 (58.7)

130/177 (73.5)

63/152 (41.5)

<0.0001

Phenotypic frequency of HLA-DRB1*04:05 (%)

172 (39.6)

92 (37.3)

80 (42.8)

NS

Phenotypic frequency of HLA-DRB1*15:01 (%)

125 (28.8)

75 (30.4)

50 (26.7)

NS