DRB1 | Total patients | Northern patients | Southern patients | ||||||
---|---|---|---|---|---|---|---|---|---|
04:05 (+) (n = 172) | 04:05 (−) (n = 262) | p value | 04:05 (+) (n = 92) | 04:05 (−) (n = 155) | p value | 04:05 (+) (n = 80) | 04:05 (−) (n = 107) | p value | |
Number of males/females (ratio) | 52/120 (1:2.3) | 68/194 (1:2.9) | NS | 27/65 (1:2.4) | 35/120 (1:3.4) | NS | 25/55 (1:2.2) | 33/74 (1:2.2) | NS |
Age (years)a | 39 (31–49) | 42 (34.2–51.5) | 0.0259 | 41 (34–49.5) | 42 (35–51) | NS | 36 (28–49) | 42 (34–52) | 0.0334 |
Age at onset (years)a | 26 (21–34.8) | 30.2 (24–40) | 0.0003 | 27 (21–34) | 29 (24–37) | NS | 25 (20–36.8) | 33 (26–43) | 0.0001 |
SPMS (%) | 26/170 (15.3) | 47/257 (18.3) | NS | 19/92 (20.7) | 34/153 (22.2) | NS | 7/78 (9.0) | 13/104 (12.5) | NS |
Disease duration (years)a | 9 (5.3–16) | 9 (4–14) | NS | 10 (6–17) | 11 (5–17) | NS | 7.5 (4–14.8) | 5.5 (3–10.3) | 0.0133 |
EDSSa | 2.0 (1.0–3.5) | 2.0 (1.0–3.5) | NS | 2.0 (1.0–3.5) | 2.0 (1.0–3.5) | NS | 2.0 (1.0–3.0) | 2.5 (1.5–4.0) | 0.0263 |
MSSSa | 2.10 (0.78–5.24) | 3.17 (1.16–5.87) | 0.0415 | 1.97 (0.56–5.63) | 2.33 (0.88–4.94) | NS | 2.28 (1.04–4.97) | 4.32 (1.77–6.33) | 0.0021 |
ARRa | 0.40 (0.22–0.71) | 0.43 (0.22–0.85) | NS | 0.40 (0.25–0.71) | 0.42 (0.22–0.75) | NS | 0.37 (0.17–0.71) | 0.48 (0.21–0.95) | NS |
Barkhof criteria (%) | 113/170 (66.5) | 205/258 (79.5) | 0.0026 | 69/92 (75.0) | 129/155 (83.2) | NS | 44/78 (56.4) | 76/103 (73.8) | 0.0143 |
Positive OB and/or increased IgG index (%) | 58/129 (45.0) | 135/200 (67.5) | <0.0001 | 41/69 (59.4) | 89/108 (82.4) | 0.0007 | 17/60 (28.3) | 46/92 (50.0) | 0.008 |