Skip to main content
Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models

Fig. 2

Inhibitory effects of bullatine A administered subcutaneously, in a single dose (3 mg/kg) or the cumulative dose range of 0.3 to 30 mg/kg, on mechanical allodynia and heat hyperalgesia in neuropathic (a–e) and diabetic (f–h) rats. Neuropathic pain was induced by tight ligation of L5/L6 spinal nerves, and diabetic neuropathic pain was induced by intravenous injection of streptozotocin (40 mg/kg). e, h Dose–response analysis of bullatine A on % maximum possible effect (% MPE) at 1 h after injection was best projected by the non-linear least-squares method. The data are presented as means ± SEM (n = 6 in each group). Symbol a denotes statistical significance compared with the saline control group (P < 0.05, two-way ANOVA followed by the post hoc Student–Newman–Keuls tests)

Back to article page