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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: MicroRNA-155 enhances T cell trafficking and antiviral effector function in a model of coronavirus-induced neurologic disease

Fig. 5

Chemokine receptor expression on virus-specific WT and miR-155 −/− mice. WT and miR-155 −/− mice were infected i.p. with DM-MHV and spleens were isolated at day 8 p.i.. Flow cytometric analysis revealed similar levels of CXCR3 on virus-specific CD4+ T cells isolated from WT and miR-155 −/− mice (a, b). However, expression of CXCR3 was decreased (p < 0.05) on virus-specific CD8+ T cells isolated from miR-155 −/− mice compared to WT mice (c, d). Flow cytometric analysis revealed similar levels of CCR5 on both virus-specific CD4+ T cells (e, f) and virus-specific CD8+ T cells (g, h) isolated from WT and miR-155 −/− mice. Plots represent average ± SEM; statistical significance was measured using unpaired, one-tailed Student’s T tests. Data are representative of two independent experiments, with a minimum of four mice per group per experiment. * p < 0.05; ** p < 0.01

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