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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET

Fig. 6

Obesity and Aβ-triggered hyperactive cerebral metabolism detected by in vivo PET with 18F-FDG. a Hippocampal 18F-FDG time activity curves in control versus obese mice. b Group comparison of cerebral metabolism assessed by 18F-FDG accumulation in the hippocampus and cerebellum. Obesity combined with Aβ infusion synergistically increased radioligand accumulation in the hippocampus but not in the cerebellum. c Representative coronal 18F-FDG PET images in vehicle or Aβ-infused control (top panel) and obese mice (bottom panel). A marked increase in radioactivity was observed in the hippocampus (indicated by dashed line, left panel) and underlying limbic structures. No effect of treatment was observed on radioactivity in the cerebellum (indicated by white dashed line, right panel). Images were generated by summation of dynamic data between 0 and 90 min after injection of 18F-FDG and were overlaid on the MRI template. *p < 0.05

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