Table 1 Multivariate linear regression analysis of serum and hippocampal cytokines associated with in vivo hippocampal 11C-PBR-28 uptake assessed by PET
From: Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET
Cytokine | 11C-PBR-28 correlation | Multiple regression weights | |||
|---|---|---|---|---|---|
b | β | ||||
Serum | Predictors | TIMP-1 | 0.075 | 0.0011** | 2.3454 |
CXCL1 | −0.129 | −0.0008** | −1.9194 | ||
CXCL2 | 0.25 | 0.0040** | 1.6419 | ||
CCL3 | −0.057 | −0.0026** | −1.5286 | ||
CCL5 | 0.038 | 0.0023** | 0.8512 | ||
IL-1β | 0.053 | −0.0012** | −0.6740 | ||
IL-13 | 0.281 | 0.0002** | 0.5435 | ||
CXCL12 | −0.099 | 0.0002** | 0.3181 | ||
CXCL13 | 0.137 | −0.0003** | −0.2792 | ||
Correlates | M-CSF | 0.650** | |||
IL-2 | 0.537* | ||||
Hippocampus | Predictors | CXCL13 | 0.045 | −0.0024** | −2.923 |
G-CSF | 0.069 | 0.0074** | 2.159 | ||
IL-1ra | 0.641* | 0.0072** | 1.550 | ||
IL-6 | −0.531* | −0.0001** | −0.518 | ||
CXCL12 | 0.389 | −0.0008** | −0.625 | ||
sICAM-1 | −0.245 | −0.0008* | −0.474 | ||
Correlates | CCL17 | −0.838*** | |||
CCL3 | 0.691** | ||||
CCL2 | 0.637* | ||||
CXCL9 | 0.634* | ||||
TIMP-1 | 0.522* | ||||
CCL5 | 0.553* | ||||