Skip to main content

Advertisement

Table 1 Multivariate linear regression analysis of serum and hippocampal cytokines associated with in vivo hippocampal 11C-PBR-28 uptake assessed by PET

From: Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET

   Cytokine 11C-PBR-28 correlation Multiple regression weights
b β
Serum Predictors TIMP-1 0.075 0.0011** 2.3454
CXCL1 −0.129 −0.0008** −1.9194
CXCL2 0.25 0.0040** 1.6419
CCL3 −0.057 −0.0026** −1.5286
CCL5 0.038 0.0023** 0.8512
IL-1β 0.053 −0.0012** −0.6740
IL-13 0.281 0.0002** 0.5435
CXCL12 −0.099 0.0002** 0.3181
CXCL13 0.137 −0.0003** −0.2792
Correlates M-CSF 0.650**   
IL-2 0.537*   
Hippocampus Predictors CXCL13 0.045 −0.0024** −2.923
G-CSF 0.069 0.0074** 2.159
IL-1ra 0.641* 0.0072** 1.550
IL-6 −0.531* −0.0001** −0.518
CXCL12 0.389 −0.0008** −0.625
sICAM-1 −0.245 −0.0008* −0.474
Correlates CCL17 −0.838***   
CCL3 0.691**   
CCL2 0.637*   
CXCL9 0.634*   
TIMP-1 0.522*   
CCL5 0.553*   
  1. Abbreviations: b unstandardized coefficients, β standardized coefficients, TIMP-1 tissue inhibitor of metalloproteinases, M-CSF macrophage colony-stimulating factor, IL-2 interleukin 2, G-CSF granulocyte colony-stimulating factor, IL-ra interleukin 1 receptor antagonist, IL-6 interleukin 6, ICAM-1 intracellular adhesion molecule 1
  2. *p < 0.05; **p < 0.01; ***p < 0.001