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Table 1 Association of excess TNF and glutamate in brain in neurodegenerative states. See text for references

From: Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents

Disease Excess brain TNF Excess brain glutamate
Alzheimer’s disease + +
Parkinson’s disease + +
Huntington’s disease + +
Amyotropic lateral sclerosis + +
Septic encephalopathy + +
Traumatic brain injury + +
Stroke + +
Poor post-operative cognition + +
Poor post-irradiation cognition + +
Poor post-chemotherapy cognition + ?
Poor cognition in rheumatoid arthritis + ?
Epileptic seizures + +
HIV dementia + +
Cerebral malaria + +
Neurogenic pain + +
Viral encephalitides + +