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Table 2 Outcome of administering specific or non-specific anti-TNF agents in states exhibiting excess cerebral TNF and the opposing effects of TNF and anti-TNF agents of brain glutamate levels. See text for references

From: Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents

  Excess cerebral TNF present Positive outcome after etanercept, etc. Positive non-specific TNF inhibitors outcome   
    Thalid or dithio-thalid Nilotinib Cannabinoids
Alzheimer’s disease + + + + +
Parkinson’s disease + ? ? + +
Huntington’s disease + ? ? ? ?
Amyotropic lateral sclerosis + + ? ? ?
Septic encephalopathy + ? ? ? ?
Traumatic brain injury + + + ? +
Stroke + + + ? ?
Poor post-operative cognition + + ? ? ?
Poor post-chemother cognition + ? ? ? ?
Poor post-irradiation cognition + ? ? ? ?
Epileptic seizures + ? ? ? +
HIV dementia + ? ? ? +
Neurogenic pain + + ? ? +
Viral encephalitides + ? ? ? +
Elevated brain glutamate +     
Lower brain glutamate   + ? ? +