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Table 1 Intracerebroventricular deferoxamine dose-tolerance chart

From: Heme oxygenase-1-mediated neuroprotection in subarachnoid hemorrhage via intracerebroventricular deferoxamine

ICV dose

Total mice tested

Tolerance

0.8 mg/kg (~0.02 mg per mouse)

3

Well tolerated

8 mg/kga (~0.2 mg per mouse)

3

Well tolerated

80 mg/kg (~2 mg per mouse)

2

Immediately died

  1. Wild-type mice were injected with a one-time intracerebroventricular (ICV) dose of deferoxamine diluted in normal saline, to test how well each dose would be tolerated
  2. aThe highest dose tolerated was chosen for all experimental procedures
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Journal of Neuroinflammation

ISSN: 1742-2094