Fig. 3
From: Loss of Schwann cell plasticity in chronic inflammatory demyelinating polyneuropathy (CIDP)
a Fluorescent staining of Schwann cells with S100 (S100) and phallodin (control and CIDP) stain. Staining with phalloidin shows the change in morphology of Schwann cells without (control) and with (CIDP) treatment with CIDP. Note morphological differences between phallodin and S100 staining. b Relative mRNA expression of p57kip2 and c-Jun in rat Schwann cells treated with CIDP sera. P57kip2 and c-Jun are significantly down-regulated after treatment with CIDP sera. c Relative mRNA expression of p57kip2 and c-Jun is decreased in human Schwann cells after treatment with CIDP sera. Human Schwann cells showed significant down-regulation to a similar extent after treatment with CIDP sera. d There is no significant down-regulation after treatment with IgG fractions from sera. GAPDH was used as a housekeeping gene. **p < 0.01, ****p < 0.0001 (unpaired Student’s t test) (scale bar = 40 μm)