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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome

Fig. 9

Examples of optic nerve lesions detected by MRI. a, b T2-weighted (a) and T1-weighted (B, with Gd) MRI reveals swelling and Gd enhancement of the left optic nerve. c, d (fat-suppressed): Longitudinal extensive Gd enhancement of the optic nerve (see cases 9 and 12 in part 3 [31] for details). e Longitudinally extensive bilateral optic neuritis extending from the chiasm (E, black arrows) into the orbits, affecting the left more than the right optic nerve. f-h Coronal T1-weighted MRIs display marked contrast enhancement of the intraorbital optic nerve as well as concurrent enhancement of the perioptic nerve sheath, partly extending in the surrounding orbital fat, in patients with acute ON (cases 11, 29 and 19). I: Axial T1-weighted MRI shows Gd enhancement along the right optic nerve in another patient (see case 13 in part 3 of this article series [31]). j, k Axial FLAIR imaging demonstrates bilateral lesions in the optic tract (see case 8 in part 3 [31] for details) (j MRI at attack onset; k follow-up MRI 1 month later)

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