| #1 | #2 | #3 | #4 | #5 | #6 | #7 | #8 | #9 | #10 | #11 | #12 | #13 | #14 | #15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sex | Ff | f | f | f | f | f | m | m | m | m | f | f | f | f | f |
Ethnicity | Cauc | Cauc | Cauc | Cauc | Cauc | Cauc | Cauc | Cauc | Cauc | Cauc | Cauc | Cauc | Cauc | Cauc | Cauc |
BSTI at onset | y | y | n | n | n | n | n | n | y | y | y | y | n | y | n |
Age at first evidence for BSTI (years) | 53 | 18 | 45 | 35 | 31 | 53 | 19 | 19 | 50 | 37 | 44 | 27 | 26 | 25 | 22 |
Time to first evidence for BSTI (years) | 0 | 0 | 18 | 0.75 | 0.25 | 41 | 0.3 | 0.17 | 0 | 0 | 0 | 0 | 1.7 | 0 | 0 |
No of clinical BST attacks | 5 | 1 | 2 | 3 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 1 |
No of attacks with subclinical BSTI | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Clinical BST findings | Central hypoventilation, dysphagia, dysarthria, CN III and VII paresis | Respiratory impairment, difficulties coughing, dysphagia, dysarthria, diplopia | Cerebellar gait and upper limb ataxia | Impaired balance, vertigo | Intractable nausea and vomiting | None, subclinical BST involvement | Double vision and gait ataxia | Hearing loss | None, subclinical BST involvement | Trigeminal hypesthesia | None, subclinical BST involvement | Trigeminal hyp- and paresthesia, diplopia, nystagmus, unsteady gait | Hypesthesia tongue and face, impaired smooth pursuit | Hemihypesthesia including the face | INO |
Infratentorial MRI findings | MRI1: Cerebral peduncle of the midbrain, MO, pons, MRI2: MO, new T2 lesions, Gd+, MRI3: pedunculus cerebellaris, crus cerebri, patchy Gd + pons, MO | Pontine tegmentum and cerebellar peduncles | Crus cerebri and entire pons, around the 4th ventricle, extending into the left cerebellar hemisphere | Pons and medulla oblongata | Right and left dorsal MO, ad-jacent to the 4th ventricle, incl. the area postrema | MO with patchy Gd enhancement | Lesions in the peri-aqueductal gray, ventral pons | T2 lesion in the pons | Median pontine lesion | N.d. | Cerebellar peduncle, single lesion | T2 lesions extending from the ponto-med. junction, throughout the MO to C5, incl. around the 4th ventricle | T2 lesions in the MO and pons, detectable over a period of at least 12 months | Bilateral pontine lesions and bilateral cerebellar peduncle lesions | Large, Gd + lesion: pons bilat., both pedunculi cerebelli, paramedian ponto-medullary junction |
 Cerebral peduncles | y | n | y | n | n | n | n | n | n | n.d. | n | n | n | n | n |
 Pons | y | y | y | y | n.d. | n | y | y | y | n.d. | n | y | y | y | y |
 Cerebellar peduncles | y | y | n | n | n | n | n | n | n | n.d. | y | n | n | y | y |
 Cerebellum | n | n | y | n | n | n | n | n | n | n.d. | n | n | n | n | n |
 Medulla oblongata | y | n | y | y | y | y | n | n | n | n.d. | n | y | y | n | y |
 Bulbo-spinal lesion, ever | y | n | n | y | y | y | n | n | n | n.d. | n | y | n | n | n |
 Gd+, ever | y | n | y | y | y | y | y | y | y | n.d. | n.d. | n | n | n.d. | y |
Supratentorial MRI findings | Normal | T2-hyperintense lesions in the frontal and parietal subcortical white matter | Crus cerebri, left subcort. white matter (adjacent to the temporal horn), corpus callosum, juxtacortical regions of parietal lobes | Lateral ventricular lesions | Normal | Normal | Confluent T2 hyperintense lesions in the right temporal lobe, pulvinar bilaterally | T2 lesions in basal ganglia, corpus callosum, periventr., pulvinar thalami, rostral putamen; leptomeningeal contrast enhancement | Normal | Normal | Single frontal lobe lesion | Juxta-cortical T2 lesion, insular region | Callosal, periventr., juxtacortical, deep white matter | Single small lesion directly adjacent to the left lateral ventricle | Peritrigonally and corona radiate, Gd+ |
Postinfectious/postvaccinal | n | y | n | n | n | y | n | y | y | n | n.d. | n | n | y | n |
Simultaneous ON and BSTI | y | n | n | n | n | n | n | y | y | y | n | y | n | n | n |
Simultaneous MY and BSTI | y | y | n | y | y | y | y | y | y | y | y | y | y | n | y |
History of both ON and MY | y | n | n | y | y | y | y | y | y | y | y | y | y | n | y |
Recurrent disease | y | n | y | y | y | y | y | y | y | n | y | y | y | y | y |
NMOSD 2015 | n | n | y | y | y | n | y | y | n | n | y | y | y | n | y |
CSF-restr. OCB | n | n | n | y | n.d. | n | y | y | n | n | n | n | y | n | n |
CSF WCC | normal | 360 | 50 | normal | 122 | 30 | 22 | 60 | normal | 8 | n.d. | 59 | 33 | 150 | 8 |
CSF neutrohils | n.a. | 7Â % | 6Â % | n.a. | 3Â % | n.d. | 6Â % | 26Â % | n.a. | 34Â % | n.d. | n.a. | n.d. | 26Â % | n.d. |
QAlb elevated | n.d. | y | n.d. | n | n | y | n | y | n | n | n.d. | n | n | y | y |
Last EDSS | 10 | 1 | 7.5 | 3 | 3 | 4.5 | 1 | 0 | 1 | 0 | 2.5 | 0 | 3.5 | 3 | 0.5 |