Fig. 1

Sample images from patient 1. a Sample images from a peripapillary ring scan. On the left, a scanning laser ophthalmoscopy image shows scan positioning (in green). On the right, an OCT scan shows severe peripapillary retinal nerve fiber layer (pRNFL) loss (between the inner limiting membrane [ILM], shown in red, and the lower border, in turquoise). b Ring-scan data in comparison with normative device data from both eyes of this patient. Black numbers display the thickness measurements (in μm) of the subject, green numbers the average thickness in the age-matched reference group. Sectors are classified in comparison with the reference group: green, thickness values within the 5th and 95th percentile range; yellow, 1st to 5th percentile range; red, below the 1st percentile. Abbreviations: G global, NS nasal-superior, N nasal, NI nasal-inferior, TI temporal-inferior, T temporal, TS temporal-superior. c Macular scan of the same patient. On the left, the dark, sickle-shaped area on and around the macula represents tissue with microcysts in the inner nuclear layer (INL). The white circle indicates the 6-mm-diameter cylinder in which intraretinal layers are analyzed. The green line with arrow shows the scanning position of the OCT scan on the right. Here, the defined layers are the RNFL, the ganglion cell and inner plexiform layer (GCIP), then INL and the outer retinal layers (ORL). Macular microcysts can be seen as small black dots in the INL