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Table 2 Structural and functional data of MOG-IgG-positive patients’ ON eyes in comparison to AQP4-IgG-positive patients and control data

From: MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 4: Afferent visual system damage after optic neuritis in MOG-IgG-seropositive versus AQP4-IgG-seropositive patients

 

MOG-IgG positive ON (n = 23 eyes from 14 subjects)

AQP4-IgG positive ON (n = 21 eyes from 14 subjects)

HC (n = 28 eyes from 14 subjects)

MOG-IgG positive vs. AQP4-IgG positive (GEE)

MOG-IgG positive vs. HC (GEE)

B

SE

p

B

SE

p

Retinal OCT

 Average pRNFL (μm)

59 ± 23

59 ± 21

99 ± 6

−0.6

7.58

0.94

39.0

6.01

<0.001

 Nasal pRNFL (μm)

44 ± 21

45 ± 24

74 ± 12

0.2

7.85

0.98

28.6

6.01

<0.001

 Temporal pRNFL (μm)

44 ± 16

40 ± 15

71 ± 10

−3.0

4.51

0.50

27.6

4.26

<0.001

 GCIP (mm3)

1.50 ± 0.34

1.41 ± 0.27

1.97 ± 0.11

−0.10

0.10

0.35

0.47

0.08

<0.001

 INL (mm3)

1.03 ± 0.10

1.01 ± 0.11

0.95 ± 0.04

−0.02

0.04

0.55

−0.07

0.03

0.009

 ORL (mm3)

4.86 ± 0.26

4.93 ± 0.26

4.73 ± 0.21

0.04

0.09

0.70

−0.13

0.09

0.14

 Eyes with macular microcysts (n)

5 (21.7 %)

4 (19.0 %)

 

Chi2

>0.99

   

Visual function

 Visual acuity/logMAR

0.35 ± 0.88

0.72 ± 1.09

-

0.33

0.32

0.30

   

 Abnormal P100 latency*

12 (57 %)

10 (50 %)

-

Chi2

0.88

   
  1. OCT and visual function results are not including data from the two patients with early stage dry macular degeneration in both eyes and glaucoma, respectively, and their respective AQP4-IgG-positive controls and healthy controls. Furthermore, two eyes of two MOG-IgG positive patients were excluded due to acute ON at time of examination. Explanations: All data are given as mean ± standard deviation (minimum – maximum), if not declared different
  2. AQP4-IgG aquaporin-4 antibody-seropositive NMOSD patients, GCIP ganglion cell and inner plexiform layer, HC healthy controls, INL inner nuclear layer, ON eyes with history of optic neuritis, MOG-IgG myelin oligodendrocyte glycoprotein antibody-seropositive patients, ORL outer retinal layers including layer from outer plexiform layer to Bruch’s membrane, pRNFL peripapillary retinal nerve fiber layer
  3. p-values in bold emphasis depict significant values (p < 0.05)
  4. * VEP data were available for 20 out of 23 ON eyes of MOG-IgG positive patients and 20 out of 21 eyes of AQP4-IgG positive patients