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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Brain omega-3 polyunsaturated fatty acids modulate microglia cell number and morphology in response to intracerebroventricular amyloid-β 1-40 in mice

Fig. 2

ad Iba1-labelled microglia cell counts (±SEM) normalized to non-surgery counts in the hippocampus regions CA1 (a), CA2 (b), CA3 (c), and dentate gyrus (d). e Representative images of the CA1 region of wild type mice fed safflower oil (WTSO), fat-1 transgenic mice fed safflower oil (fat-1), and wild type mice fed fish oil (WTFO) prior to surgery (baseline, top two rows) and at 10 days post intracerebroventricular infusion of amyloid-β peptide (bottom two rows). The top rows for each time point are images enhanced for contrast and sharpness for publication; bottom images are the same images in which a threshold was applied to show labelled cells. Two-way ANOVA was applied; significant main effects and interactions are reported beneath each graph. Different letters denote significantly different bars within a time point (e.g., 10 days post-surgery), while lines and asterisks indicate overall differences between time points. *p < 0.05, **p < 0.01. CA cornu ammonis, DG dentate gyrus, iba1 ionized calcium-binding adapter molecule 1. SEM standard error of the mean

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