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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and l-type Ca2+ channels upstream of p38 MAPK

Fig. 5

Ca2+ channel blockers limit activity of p38 MAPK in cerebrocortical cells upon exposure to CXCL12. Rat cerebrocortical cells were incubated for the indicated time periods with CXCL12 (20 nM) in the presence or absence of MK-801 (10 μM) or nimodipine (10 nM), prior to cell lysis on ice. 30 μg of protein per lane were analyzed by Western blotting using the specific antibodies against the indicated molecules. A representative immunoblot is shown for each time point. Quantification by densitometry; n = 3 to 4 per time point; *P ≤ 0.05, **P ≤ 0.01 by ANOVA followed by Fisher’s PLSD post hoc test

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