Fig. 7

Pharmacological inhibition of p38 MAPK protects cerebrocortical neurons from toxicity of CXCL12. Cerebrocortical cell cultures were incubated with CXCL12 (20 nM) in the presence and absence of p38 MAPK inhibitor SB203580 (SB, 10 μM) for 24 h. Analysis of neuronal survival was performed as described in the “Methods” section using staining for neurons (MAP-2) and nuclear DNA (H33342). Values are mean ± SEM; n ≥ 3 with duplicate or triplicate samples per condition; **P ≤ 0.01, ***P ≤ 0.001 by ANOVA followed by Fisher’s PLSD post hoc test