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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Loss of cerebellar neurons in the progression of lentiviral disease: effects of CNS-permeant antiretroviral therapy

Fig. 2

Quantification of SIV gp41 + (a), CD68+ (c), and CD163+ (d) cells and neuroinflammatory activity score (b). SIV gp41 + cells were detected only in the cerebellum of the SIV/+AIDS group (8.23 ± 2.16/mm2) (a). This correlates with a high score in neuroinflammatory activity (4.83 ± 1.33) (b). 6-Cl-ddG significantly reduces neuroinflammation (0.67 ± 0.82), but not to base level as seen in the control group (0 ± 0). A subliminal neuroinflammatory activity remains, like in the SIV/-AIDS group (1 ± 0). The number of CD68+ cells is significantly increased in the SIV/+AIDS group (259.5 ± 53.7/mm2) compared to the control group (56.6 ± 16.2/mm2) and the SIV/-AIDS group (110.5 ± 35.4/mm2) (c). 6-Cl-ddG significantly reduces CD68+ cell count to base level (50.8 ± 20.1/mm2). CD68+ cells show a predominantly parenchymal location. The total number of CD163+ cells is increased in the SIV/+AIDS group (943.6 ± 69.5/cm2) compared to the control group (38.4 ± 3.3/cm2) and the SIV/-AIDS group (80.0 ± 53.5/cm2). 6-Cl-ddG reduces significantly the total number of CD163+ cells (374.3 ± 12.5/cm2), but the number of intravascular and perivascular CD163+ cells is constantly high (33.1 ± 4.9 vs. 28.9 ± 8/cm2). Illustration of mean values (MV) and standard deviation (SD) (MV ± SD). **p value <0.01, ***p value <0.001

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