Fig. 3

Astrogliosis and Bergmann gliosis. Representative slices stained for GFAP. Note the extensive astrogliosis and Bergmann gliosis in the SIV/+AIDS group (d–f) with focal rarefication of astroglial structures (e). The inset in e shows a hypertrophic astrocyte. g–i showing a molecular layer. Note the distinct hypertrophy of Bergmann glia in the SIV/+AIDS group (f). 6-Cl-ddG treatment reduces astrogliotic reactions in white matter and molecular layer (g–i), but not to base level as seen in the control group (a–c). Scale bar (in a) 500 μm in a, d, g; 62.5 μm in b, c, e, f, h, i; 20 μm in insets. ML molecular layer, PL Purkinje layer, GL granular layer, WM white matter