Loss of cerebellar neurons in the progression of lentiviral disease: effects of CNS-permeant antiretroviral therapy

Table 1 Infection status, treatment regime, and clinical status at time of death and necropsy of the macaques used

Group	Monkey number	SIV deltaB670 inoculation	AIDS^a	ART^b
Control	44	No	No	No
	50	No	No	No
	69	No	No	No
	87	No	No	No
	88	No	No	No
SIV/-AIDS	75	Yes	No	No
	80	Yes	No	No
	85	Yes	No	No
	92	Yes	No	No
	93	Yes	No	No
SIV/+AIDS	71	Yes	Yes	No
	74	Yes	Yes	No
	78	Yes	Yes	No
	79	Yes	Yes	No
	82	Yes	Yes	No
	86	Yes	Yes	No
SIV/+AIDS/+6-Cl-ddG	70	Yes	Yes	Yes
	72	Yes	Yes	Yes
	73	Yes	Yes	Yes
	76	Yes	Yes	Yes
	77	Yes	Yes	Yes
	83	Yes	Yes	Yes
	89	Yes	Yes	Yes^c
	91	Yes	Yes	Yes

^aClinical manifestation of acquired immunodeficiency syndrome
^bAdministration of 2,3-ddl (10 mg/kg s. c. daily) for 3 weeks, following 6-Cl-ddG (75 mg/kg s. c. daily) for 6 weeks
^cSole administration of 6-Cl-ddG (75 mg/kg s. c. daily) for 3 weeks

ISSN: 1742-2094