Mediatora (pg/g tissue) | Hippocampus | Entorhinal cortex | Temporal cortex | MANOVA, brain region P valueb | Two-way ANOVA, epilepsy (±) × region P valuec | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SEM | N | Mean | SEM | N | Mean | SEM | N | |||
Eotaxin | 627**** | 67 | 51 | 404 | 40 | 62 | 307 | 42 | 59 | <0.0001 | <0.0001 |
IP-10 | 3597** | 453 | 51 | 6213 | 1292 | 59 | 7004 | 1413 | 59 | 0.0306 | 0.0038 |
MCP-1 | 8051 | 1199 | 51 | 4551* | 465 | 60 | 8440 | 1803 | 58 | 0.0045 | 0.1923 |
MCP-4 | 839 | 89 | 51 | 545* | 35 | 62 | 676 | 152 | 57 | 0.0011 | 0.3751 |
MIP-1α | 1008 | 189 | 51 | 590 | 124 | 62 | 2187**** | 361 | 59 | 0.0001 | <0.0001 |
MIP-1β | 2362 | 311 | 51 | 1636 | 208 | 61 | 3306*** | 437 | 59 | 0.0037 | 0.0153 |
TARC | 666 | 111 | 51 | 501 | 49 | 61 | 855 | 205 | 59 | 0.1047 | 0.3991 |
GM-CSFd | 3062 | 710 | 51 | 470**** | 230 | 62 | 2579 | 400 | 59 | <0.0001 | 0.0009 |
IFN-γd | 33.1**** | 10.9 | 51 | 0 | 0 | 62 | 1.56 | 1.56 | 59 | 0.0143 | 0.0008 |
IL-1α | 992** | 162 | 51 | 3616** | 372 | 62 | 2576** | 271 | 58 | <0.0001 | <0.0001 |
IL-1β | 13.8** | 2.2 | 51 | 27.8** | 3.9 | 62 | 39.7** | 5.0 | 57 | <0.0001 | 0.0002 |
IL-2d | 38.3**** | 7.9 | 49 | 4.16 | 1.83 | 62 | 7.97 | 2.27 | 59 | <0.0001 | <0.0001 |
IL-4 | 11.7**** | 1.2 | 49 | 7.17 | 0.40 | 62 | 6.45 | 0.44 | 59 | 0.0010 | <0.0001 |
IL-6 | 33.4 | 8.2 | 51 | 34.8 | 8.5 | 60 | 60.8 | 15.2 | 57 | 0.1409 | 0.0161 |
IL-8 | 570 | 121 | 51 | 933 | 251 | 61 | 1473* | 331 | 57 | 0.0029 | 0.0259 |
IL-10d | 4.21 | 0.75 | 51 | 1.49** | 0.47 | 61 | 3.37 | 0.85 | 59 | 0.0225 | 0.1399 |
IL-12/23 p40 | 72.9 | 14.8 | 51 | 97.9 | 12.8 | 61 | 88.2 | 13.3 | 58 | 0.1490 | 0.1273 |
IL-12 p70 | 5.17 | 0.68 | 50 | 2.65*** | 0.43 | 62 | 3.59 | 0.29 | 58 | 0.0494 | 0.0019 |
IL-17A | 949**** | 112 | 49 | 378 | 44 | 62 | 252 | 28 | 59 | <0.0001 | <0.0001 |
TNF-α | 5.89 | 0.75 | 51 | 3.16 | 0.67 | 60 | 5.26 | 0.85 | 57 | 0.1176 | 0.0518 |
TNF-β | 3.85 | 0.89 | 49 | 8.52**** | 0.58 | 62 | 4.90 | 0.56 | 59 | 0.0143 | <0.0001 |
VEGF | 7716*** | 1865 | 49 | 3553 | 1199 | 62 | 1889 | 720 | 59 | 0.0231 | 0.0465 |
CRP | 26,540 | 2222 | 49 | 22,069 | 1435 | 62 | 15,624**** | 1115 | 59 | <0.0001 | <0.0001 |
ICAM-1 | 12,088** | 1110 | 50 | 9243 | 786 | 62 | 8291 | 897 | 58 | 0.0035 | <0.0001 |
VCAM-1 | 21,887 | 4754 | 51 | 21,351 | 3659 | 62 | 14,427 | 2632 | 59 | 0.0103 | <0.0001 |