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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes

Fig. 2

The activity of PPARγ affected the improvement of depression-like behaviors. a The principle scheme of the experimental project. BW at the baseline level (b) and the sixth week (c) (n = 10). SP showed no differences at week 0 (d). Pioglitazone improved the ratio of the SP in CMS mice but anhedonia was maintained with the antagonist of PPARγ, GW9662, administration (e, n = 10). Spontaneous activity was modulated by pioglitazone and GW9662 (f, n = 8). Pioglitazone decreased the time of immobility, but GW9662 increased the immobility duration in the FST and TST (g, h, n = 8 in both tests). * p < 0.05, ** p < 0.01 vs. Control; # p < 0.05, ## p < 0.01 vs. CMS + Vehicle; $$ p < 0.01 vs. CMS + Piog. Data are expressed as means ± SEM

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