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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes

Fig. 7

The M2 molecules: Ym1 (a), Arg1 (b), IL-4 (c), IL-10 (d), and TGFβ (e) decreased with LPS treatment. Pioglitazone increased the expression of the M2 markers. The impact on the LPS+Piog+GW group was similar to that of the LPS microglial cells. The level of Ym1 (f & g) and Arg1 (h & i) was also confirmed by western blot. The protein expression of IκBα decreased in LPS-stimulated cells; pioglitazone significantly ameliorated the expression. GW9662 suppressed the rise after pioglitazone-treated LPS in microglia (j & k).* p < 0.05, ** p < 0.01 vs. Control; # p < 0.05, ## p < 0.01. Data are expressed as means ± SEM

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