TY - JOUR AU - Nardo, Giovanni AU - Trolese, Maria Chiara AU - de Vito, Giuseppe AU - Cecchi, Roberta AU - Riva, Nilo AU - Dina, Giorgia AU - Heath, Paul R. AU - Quattrini, Angelo AU - Shaw, Pamela J. AU - Piazza, Vincenzo AU - Bendotti, Caterina PY - 2016 DA - 2016/10/07 TI - Immune response in peripheral axons delays disease progression in SOD1G93A mice JO - Journal of Neuroinflammation SP - 261 VL - 13 IS - 1 AB - Increasing evidence suggests that the immune system has a beneficial role in the progression of amyotrophic lateral sclerosis (ALS) although the mechanism remains unclear. Recently, we demonstrated that motor neurons (MNs) of C57SOD1G93A mice with slow disease progression activate molecules classically involved in the cross-talk with the immune system. This happens a lot less in 129SvSOD1G93A mice which, while expressing the same amount of transgene, had faster disease progression and earlier axonal damage. The present study investigated whether and how the immune response is involved in the preservation of motor axons in the mouse model of familial ALS with a more benign disease course. SN - 1742-2094 UR - https://doi.org/10.1186/s12974-016-0732-2 DO - 10.1186/s12974-016-0732-2 ID - Nardo2016 ER -