Fig. 1
From: Immune response in peripheral axons delays disease progression in SOD1G93A mice
Muscle innervation is more impaired in fast- (129SvSOD1G93A) than in slow-progressing C57SOD1G93A mice. a, b Denervation was analyzed in tibialis anterior muscle of 129SvSOD1G93A and C57OD1G93A strains and Ntg littermates. a α-Bungarotoxin (BTX, red) was used to identify the postsynaptic domain; synaptophysin (SYP, green) was used to identify pre-synaptic terminals (scale bar, 50 μm). b Mean ± SEM (n = 3 mice; ~100 bungarotoxin-positive endplates per animal were randomly chosen and analyzed). ***P value <0.001 (C57G93A vs 129SvG93A); °°P value <0.01 (129SvNtg and C57Ntg vs C57G93A); #### P value <0.0001 (129SvNtg and C57Ntg vs 129SvG93A) by two-way ANOVA with Tukey’s post-analysis. c Real-time PCR for AChR-γ transcript in the TA muscles of C57SOD1G93A and 129SvSOD1G93A mice compared with the Ntg littermates. Data are normalized to β-actin and expressed as the mean (±SEM)-fold change ratio between the C57SOD1G93A mice, 129SvSOD1G93A mice, and controls (n = 4 per group). ****P value <0.0001 (C57G93A vs 129SvG93A); °°°°P value <0.0001 (129SvG93A vs NtgC57 and Ntg129Sv); by two-way ANOVA with Tukey’s post-analysis