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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Immune response in peripheral axons delays disease progression in SOD1G93A mice

Fig. 2

Sciatic nerve dysregulation of 129SvSOD1G93A mice at disease onset. a Representative western blots images of neurofilaments, acetylated tubulin, GFAP, P-ERK, and β-importin, and tubulin on sciatic nerve extracts from the C57SOD1G93A, 129SvSOD1G93A, and Ntg littermates at the onset of the disease. b–f Densitometric analysis shows reductions in the expression of b neurofilaments and c acetyl tubulin as well as specific activation of d β-importin in the sciatic nerve of the 129SvSOD1G93A mice. In addition, activation of e GFAP and f P-ERK was reduced in the sciatic nerve of the 129SvNtg and 129SvSOD1G93A mice. P-ERK levels were normalized to relative levels of ERK (not shown). Mean ± SEM (n = 4 per group). **P value <0.01; ***P value <0.001; ****P value <0.0001 (C57G93A vs 129SvG93A in b–f); °°P value <0.001; (NtgC57 vs Ntg129Sv in e and f); # P value <0.05 (129SvG93A vs NtgC57 in e); $$$$ P value <0.0001 (C57G93A vs NtgC57 and Ntg129Sv in e); § P value <0.05; §§§§ P value <0.0001 (129SvG93A vs NtgC57 and Ntg129Sv in e); (129SvG93A vs Ntg129Sv in f) by two-way ANOVA with Tukey’s post-analysis

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