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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Immune response in peripheral axons delays disease progression in SOD1G93A mice

Fig. 7

Immune cell infiltration in the PNS of transgenic ALS mice promotes Schwann cells (SCs) proliferation and axonal maintenance. Schematic representation of the PNS of C57SOD1G93A mice and 129SvSOD1G93A mice during disease progression. a In the C57SOD1 G93A mice, the activation of MHCI, autophagocytic SCs, and C3 byproducts leads to the recruitment and interaction of CD8+ T cells and macrophages at the site of injury. CD8+ T cells and macrophage coordinated activity potentiates the rate of degradation of defective SCs (and myelin debris) in order to stimulate the de-differentiation and proliferation of SCs and, finally, the remyelination of motor axons and NMJs. b In the 129SvSOD1G93A mice, the lower phagocytic activity of SCs/macrophage and the lack of CD8+ T cell infiltration result in less removal of defective SCs in addition to reduced SCs de-differentiation/proliferation which lead to earlier muscle denervation

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