Fig. 1
From: EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis
SS2 strain SC19 infection induced a strong neuroinflammation. a Increasing adherence of SC19 to hBMEC along with time. b 5-week-old CD1 mice were injected intravenously with 2 × 108 CFU SC19 strain. The histopathological changes of the brain in infected mice were investigated. (a, d) Normal cerebral meninges and brain tissue, (b) meningeal thickening, (c) subdural hemorrhage, (e) perivascular inflammatory infiltrates, (f) slight neuronophagia, and (g) partial magnification of panel (f). Scale bar = 50 μm. c Brain lysates and serum were harvested at various time points post infection and cytokines production were determined by Q-Plex™ Chemiluminescent ELISA. Results were expressed as the mean ± SD from three infected mice at each time point. Statistical analysis was carried out between the infected group at each time point and the uninfected group (0 h). d Total RNAs of infected and uninfected hBMEC were extracted and reversely transcribed. The mRNA levels of cytokines and chemokines were markedly increased in response to SC19 stimulation