Fig. 5
From: EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis
EGFR selective inhibitor AG1478 could significantly attenuate the SS2-induced neuroinflammation. a SC19 infection of hBMEC induced a time-dependent increase of the proinflammatory cytokines and chemokines, while this could be significantly blocked by the treatment of AG1478. b Serum and brains lysates were collected from challenged mice with or without AG1478 pretreatment. The levels of representative cytokine and chemokine, IL-6 and MCP-1, were determined and compared. Results were expressed as mean ± SD of three infected mice in each group