Fig. 4
From: Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides
Effects of polarized macrophages transferred at the nerves on sensitivity following CCI and sham surgery. a, b Effects of M0, M1, and M2 macrophages on mechanical (a) and heat hypersensitivity (b) following CCI. c, d Effects of M0, M1, and M2 macrophages on mechanical (c) and heat sensitivity (d) following sham surgery. Macrophages or control DMEM were injected at the site of CCI or sham surgery on days 14 and 15 following surgeries (indicated by arrows). Mechanical and heat sensitivity were measured using von Frey filaments and Hargreaves test, respectively. ***p < 0.001 vs. control (DMEM); two-way RM ANOVA, Bonferroni’s test. Data show the mean ± SEM (n = 9 animals per group)