Fig. 5
From: Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides
Contribution of peripheral opioid receptors to M2 macrophage-mediated analgesia in neuropathy-induced mechanical hypersensitivity. M2 macrophages were injected on days 14 and 15 following CCI, and opioid receptor antagonist NLXM was applied on day 16 after CCI (i.e., 24 h after the second injection of macrophages). All injections (indicated by arrows) were performed at the CCI site, and the effects were assessed using von Frey filaments. ***p < 0.001 vs. vehicle; ### p < 0.001 vs. baseline measured 14 days after CCI (two-way RM ANOVA, Bonferroni’s test). Data show the mean ± SEM (n = 6 animals per group)