Skip to main content
Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship

Fig. 1

Schematic diagram of systemic inflammation- and immune depression-associated multiple organ dysfunction following SCI. SCI triggers an acute increase of inflammatory cells (such as neutrophils and macrophages) in the circulation and elevates serum concentrations of pro-inflammatory mediators. Subsequent infiltration of inflammatory cells from the blood into secondary organs initiates a series of events that mediate inflammatory responses in these organs. Activation of resident immune cells (microglia) in the brain is also found after SCI. SCI itself interrupts innervation of immune organs by the sympathetic nervous system, causing immune depression syndrome. Suppressed immunity leads to an increased susceptibility of the whole body to post-injury pathogen infections through decreased immune cell quantities (such as monocytes, T cells, and B cells)

Back to article page