Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy

Table 2 Electroneuronography and heart rate variability (HRV) findings in patient 1 at days 7 (d7), 24 (d24), 31 (d31), 40 (d40) and 62 (d62), demonstrating axonal and demyelinating sensorimotor poly(radiculo)neuropathy with lost and delayed F waves and autonomic involvement, compatible with Guillain-Barré syndrome

	CMAP [mV]	DML [ms]	mNCV [m/s]	F waves [ms]	A waves	SNAP [μV]	sNCV [m/s]
	Tibial nerve, right					Sural nerve, right
d7	10.9 (n)	3.8 (n)	41 (n)	64.3 (↑)	Yes	9.1 (n)	52.6 (n)
d24	6.8 (n)	5.2 (n)	36.7 (↓)	Lost	Yes	6.4 (n)	50 (n)
d40	2.5 (↓)	5.5 (n)	25 (↓)	Lost	N.d.	5.8 (n)	47.5 (n)
d62	0.6 (↓)	8.5 (↑)	33 (↓)	Lost	N.d.	N.d.	N.d.
	Ulnar nerve, right					Ulnar nerve, right
d7	10.6 (n)	2.5 (n)	60 (n)	29.9 (n)	N.d.	2.3 (↓)	45.8 (n)
d24	8.6 (n)	2.8 (n)	38.5 (↓)	34.6 (↑)	N.d.	N.d.	N.d.
d40	9.5 (n)	3.8 (↑)	47 (n)	42.1 (↑)	N.d.	Lost	Lost
	Facial nerve, right^a
d31		0.4 (↓ ^b )	5.2 (↑ ^b )
	Facial nerve, left^c
d31		0.9	4.3
	HRV [%]
d7	17 (n)
d24	8.7 (↓)

Note the continuous deterioration of almost all sensory and motor modalities over the course of the disease. Pathological results are printed in italicized letters
N.d. no data, CMAP compound muscle action potential, DML distal motor latency, mNCV motor nerve conduction velocity, SNAP sensory nerve action potential, sNCV sensory nerve conduction velocity; ↑ increased, ↓ decreased
^aSymptomatic
^bCompared with left facial nerve
^cAsymptomatic

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